Skopinska E
Ann Med Sect Pol Acad Sci. 1976;21(4):185-96.
Lipopolysaccharide from Escherichia coli (LPS) administered to mice during the graft-versus-host (GvH) reaction in a single dose of 100 mug stimulated the reaction if it was given on the same day as the parental spleen cells, or inhibited it if given four days before injection of the cells. The GvH reaction was intensified when LPS was injected in the dose of 20 mug on the fourth day after injection of the cells. The parental spleen cells responsible for the intestifying effect on GvH were sensitive to hydrocortisone, nonadherent, and probably develop in the course of the first week outside the donor spleen and settle in the spleen in a later stage of the GvH reaction.
在移植物抗宿主（GvH）反应期间，以100微克的单剂量给予小鼠来自大肠杆菌的脂多糖（LPS），如果在与亲代脾细胞同一天给予，则会刺激该反应；如果在注射细胞前四天给予，则会抑制该反应。当在注射细胞后第四天以20微克的剂量注射LPS时，GvH反应会增强。对GvH有增强作用的亲代脾细胞对氢化可的松敏感、不黏附，并且可能在供体脾外的第一周内发育，并在GvH反应的后期定居于脾脏。
