Hrobonová K, Lehotay J, Cizmárik J
Fakulty chemickej a potravinárskej chémie Slovenskej technickej univerzity, Bratislava.
Ceska Slov Farm. 2004 Jul;53(4):197-202.
The chiral stationary phase on the base of beta-cyclodextrin and the mobile phase acetonitrile/0.1 mol/l acetate buffer pH=5.2 (88/12 w/w) were used for the separation of the enantiomers of 1-methoxymethyl, 1-ethoxymethyl, 1-propoxymethyl-2-(1-pyrrolidinyl), (1-piperidino), (1-perhydroazepinyl)ethyl esters of 2-alkoxyphenylcarbamic acid. The influence of the structure of these compounds and the influence of temperature on enantioseparation were studied. The dominant effect on the resolution of enantiomers is exerted by the length of the alkoxysubstituent on the aromatic ring and its position with regard to the stereogenic centre. A decrease in temperature caused an increase in the retention factors of the compounds under study and the resolution values of enantiomers.
以β-环糊精为基础的手性固定相和乙腈/0.1 mol/L pH=5.2的醋酸盐缓冲液（88/12 w/w）流动相用于分离2-烷氧基苯基氨基甲酸1-甲氧基甲基、1-乙氧基甲基、1-丙氧基甲基-2-（1-吡咯烷基）、（1-哌啶基）、（1-全氢氮杂环庚烷基）乙酯的对映体。研究了这些化合物的结构以及温度对映体拆分的影响。芳环上烷氧基取代基的长度及其相对于手性中心的位置对映体的拆分起主要作用。温度降低导致所研究化合物的保留因子和对映体的拆分值增加。
