Yan Feng, Roth Bryan L
Department of Biochemistry, RM W441, Case Western Reserve University Medical School, 2109 Adelbert Road, Cleveland, OH 44106, USA.
Life Sci. 2004 Oct 15;75(22):2615-9. doi: 10.1016/j.lfs.2004.07.008.
kappa-opioid receptors (KORs) represent the principal site of action of dynorphin and related neuropeptides. Recently, Salvinorin A--a naturally occurring neoclerodane diterpene hallucinogen was identified to be a highly selective KOR agonist. In this brief review we summarize the known chemistry, pharmacology and biology of salvinorin A. Because salvinorin A profoundly alters human consciousness and perception, a study of how salvinorin A exerts its actions on KORs may yield novel insights into the molecular and cellular basis of uniquely human higher cortical functions.
κ-阿片受体（KORs）是强啡肽及相关神经肽的主要作用位点。最近，一种天然存在的新克罗烷二萜类致幻剂——Salvinorin A被鉴定为一种高度选择性的KOR激动剂。在这篇简短的综述中，我们总结了Salvinorin A已知的化学、药理学和生物学特性。由于Salvinorin A能深刻改变人类意识和感知，研究Salvinorin A如何作用于KORs可能会为独特的人类高级皮层功能的分子和细胞基础带来新的见解。
