Doyle Declan A
Structural Genomics Consortium, University of Oxford, Botnar Research Center, Oxford, OX3 7LD, UK.
Mol Membr Biol. 2004 Jul-Aug;21(4):221-5. doi: 10.1080/09687680410001716844.
Water is probably the most important molecule in biology. It solvates molecules, all biochemical reactions occur in it and it is a major driving force in protein folding. Phospholipid membranes separate different water environments, but connections do exist between the different compartments. The integral membrane proteins (IMPs) form these connections. In the case of ions, IMPs form the passageways that regulate ion movement across the membrane. Structural information from three ion distinct channels are examined to see how these channels first select for and then control the movement of their target ions. This review focuses on how these channels select for target ions and control their movement while taking into account and using different properties of water. This includes the use of hydrophobic gates, mimicking the water environment, and controlling ions indirectly by controlling water.
水可能是生物学中最重要的分子。它使分子溶剂化，所有生化反应都在其中发生，并且它是蛋白质折叠的主要驱动力。磷脂膜分隔不同的水环境，但不同隔室之间确实存在联系。整合膜蛋白（IMPs）形成这些联系。就离子而言，整合膜蛋白形成调节离子跨膜移动的通道。研究了来自三种不同离子通道的结构信息，以了解这些通道如何首先选择并随后控制其目标离子的移动。本综述重点关注这些通道如何选择目标离子并控制其移动，同时考虑并利用水的不同特性。这包括使用疏水门、模拟水环境以及通过控制水来间接控制离子。
