Huang Yi-ning, Jia Zhi-rong, Shi Xin, Sun Xiang-ru
Department of Neurology, First Hospital of Peking University, Beijing 100034, China.
Chin Med J (Engl). 2004 Sep;117(9):1317-20.
Diabetic neuropathy is common in diabetes mellitus. The early stage of diabetic neuropathy is often symptomless and difficult to be treated. The aim of this study was to assess the correlation between the results of the sympathetic skin response (SSR) test and the development of diabetic neuropathy, and explore the use of SSR as an objective basis for the early diagnosis of diabetic neuropathy.
The latencies and amplitudes of initiation and of the N and P waves were determined by SSR testing of the extremities of 80 diabetic patients and 30 healthy controls.
The latencies of initiation and of the N and P waves were significantly (P <0.001) longer in diabetic patients than in the controls, while there was no significant difference in the amplitudes (P >0.05). All but two patients (97.5%) demonstrated abnormal SSR in at least one limb.
SSR can detect early dysfunction of the small sympathetic fibers in people affected by diabetes mellitus, and may be a useful electrophysiological test for the early diagnosis of diabetic neuropathy.
糖尿病性神经病变在糖尿病患者中很常见。糖尿病性神经病变的早期通常无症状且难以治疗。本研究的目的是评估交感神经皮肤反应（SSR）测试结果与糖尿病性神经病变发展之间的相关性，并探讨将SSR用作糖尿病性神经病变早期诊断的客观依据。
通过对80例糖尿病患者和30例健康对照者的四肢进行SSR测试，测定起始潜伏期以及N波和P波的潜伏期和波幅。
糖尿病患者起始潜伏期以及N波和P波的潜伏期显著长于对照组（P<0.001），而波幅无显著差异（P>0.05）。除两名患者外（97.5%），所有患者至少有一个肢体的SSR异常。
SSR可检测出糖尿病患者小交感神经纤维的早期功能障碍，可能是糖尿病性神经病变早期诊断的一种有用的电生理测试。
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