脊椎动物中枢神经系统顶板形成的机制。

Mechanisms of roof plate formation in the vertebrate CNS.

作者信息

Chizhikov Victor V, Millen Kathleen J

机构信息

Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC 319, Chicago, Illinois 60637, USA.

出版信息

Nat Rev Neurosci. 2004 Oct;5(10):808-12. doi: 10.1038/nrn1520.

DOI:10.1038/nrn1520

PMID:15378040

Abstract

The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.

摘要

顶板是一个胚胎组织中心，位于脊椎动物神经管的背中线。在中枢神经系统早期发育过程中，顶板产生分泌因子，这些因子控制着背侧神经元细胞类型的特化和分化。对顶板信号特性的认识引发了人们对这个重要组织中心的浓厚兴趣，最近的几项研究已开始阐明顶板发育的分子机制。