Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives.
作者信息
Watkins William J, Lemoine Rémy C, Chong Lee, Cho Aesop, Renau Thomas E, Kuo Bonnie, Wong Vickie, Ludwikow Maria, Garizi Negar, Iqbal Nadeem, Barnard John, Jankowska Renata, Singh Rajeshwar, Madsen Deidre, Lolans Karen, Lomovskaya Olga, Oza Uma, Dudley Michael N
机构信息
Essential Therapeutics, Inc., 850 Maude Ave., Mountain View, CA 94043, USA.
出版信息
Bioorg Med Chem Lett. 2004 Oct 18;14(20):5133-7. doi: 10.1016/j.bmcl.2004.07.071.
PMID:15380214
Abstract
Structure-activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of Candida albicans and Candida glabrata over-expressing ABC-type efflux pumps are systematically explored.
摘要
Zotero 插件