Zhu Xiaoyan, Rosenfeld Michael G
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Curr Opin Genet Dev. 2004 Oct;14(5):567-74. doi: 10.1016/j.gde.2004.08.006.
The anterior pituitary is derived from Rathke's pouch arising from the oral ectoderm. The initial apparently uniform precursor cells proliferate and differentiate into six different cell types that are present in mature gland by integrative interactions between different signaling molecules and transcription factors. This system provides an opportunity to understand gene regulation in the cellular processes of precursor cell proliferation, determination, and differentiation events during organogenesis. Recent studies have made significant advances in our appreciation of the molecular mechanisms by which transcription factors regulate these cellular processes.
腺垂体起源于口腔外胚层的拉特克囊。最初看似均一的前体细胞通过不同信号分子和转录因子之间的整合相互作用进行增殖，并分化为成熟腺体内存在的六种不同细胞类型。该系统为理解器官发生过程中前体细胞增殖、决定和分化事件的细胞过程中的基因调控提供了一个契机。最近的研究在我们对转录因子调控这些细胞过程的分子机制的认识方面取得了重大进展。
