抗抑郁药治疗六周期间体重变化的早期预测

Early prediction of changes in weight during six weeks of treatment with antidepressants.

作者信息

Himmerich Hubertus, Schuld Andreas, Haack Monika, Kaufmann Christian, Pollmächer Thomas

机构信息

Max Planck Institute of Psychiatry, Kraepelinstrasse 10, Munich 80804, Germany.

出版信息

J Psychiatr Res. 2004 Sep-Oct;38(5):485-9. doi: 10.1016/j.jpsychires.2004.02.002.

DOI:10.1016/j.jpsychires.2004.02.002

PMID:15380398

Abstract

Weight gain is a frequent and important side effect of psychotropic treatment. We sought to determine weight change predictors during treatment with antidepressant drugs. In 24 patients weight, plasma levels of leptin, tumor necrosis factor-alpha (TNF-alpha and soluble TNF receptors were determined longitudinally and a multiple linear regression analysis was used to predict weight change from baseline to the sixth week of treatment. Changes of weight during the first week of treatment, but no other parameter, strongly predicted weight change until endpoint (adjusted R2 = 0.68, F = 50.45, df = 1,23, p < 0.001). Very early changes in weight during treatment with psychotropic drugs might be a simple and clinically useful predictor of future weight development.

摘要

体重增加是精神药物治疗常见且重要的副作用。我们试图确定抗抑郁药物治疗期间体重变化的预测因素。对24例患者纵向测定了体重、瘦素血浆水平、肿瘤坏死因子-α（TNF-α）和可溶性TNF受体，并采用多元线性回归分析预测从治疗基线到第六周的体重变化。治疗第一周的体重变化，而非其他参数，能强烈预测直至终点的体重变化（调整后R2 = 0.68，F = 50.45，自由度= 1,23，p < 0.001）。精神药物治疗期间体重的极早期变化可能是未来体重发展的一个简单且临床有用的预测指标。