Zee Robert Y L, Hegener Hillary H, Fernandez-Cruz Arturo, Lindpaintner Klaus
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA.
Atherosclerosis. 2004 Oct;176(2):393-6. doi: 10.1016/j.atherosclerosis.2004.05.022.
Recent findings have demonstrated that plasma C-reactive protein levels predict restenosis after coronary angioplasty. Furthermore, C-reactive protein levels have also been shown to be heritable. However, no genetic-epidemiological data are available on the relationship between genetic variants of C-reactive protein (CRP) gene and risk of restenosis after angioplasty. The present study was carried out to examine the possible association of a non-sense exonic 1059G > C and an intronic T > A C-reactive protein gene polymorphisms in a large, previously described, well-characterized cohort of 779 post-angioplasty patients of whom 342 subjects developed restenosis. Genotype distributions were in Hardy-Weinberg equilibrium. Genotype and allele distributions were similar between cases and controls. Haplotype frequency distributions were also similar between cases and controls. Further investigation using a haplotype-based logistic and linear regression analyses, adjusting for potential confounders, yielded similar null results. In conclusion, we found no evidence for an association between the polymorphisms/haplotypes thereof tested and restenosis after angioplasty.
最近的研究结果表明，血浆C反应蛋白水平可预测冠状动脉血管成形术后的再狭窄。此外，C反应蛋白水平也具有遗传性。然而，关于C反应蛋白（CRP）基因的遗传变异与血管成形术后再狭窄风险之间的关系，尚无遗传流行病学数据。本研究旨在检测在一个大型、先前描述的、特征明确的队列中，血管成形术后的779例患者（其中342例发生再狭窄）中，外显子1059G>C无义突变和内含子T>A C反应蛋白基因多态性之间可能存在的关联。基因型分布符合哈迪-温伯格平衡。病例组和对照组之间的基因型和等位基因分布相似。病例组和对照组之间的单倍型频率分布也相似。使用基于单倍型的逻辑回归和线性回归分析进行进一步研究，并对潜在混杂因素进行校正，得到了类似的阴性结果。总之，我们没有发现所检测的多态性/单倍型与血管成形术后再狭窄之间存在关联的证据。
