Holland Eric C
Memorial Sloan-Kettering Cancer Center, Departments of Surgery (Neurosurgery), Neurology, and Cell Biology and Genetics, 1275 York Avenue, New York, NY 10021, USA.
Cancer Cell. 2004 Sep;6(3):197-8. doi: 10.1016/j.ccr.2004.09.004.
Histologically accurate mouse models of human cancers generated by somatic or germline genetic modification strategies recapitulate the genetic alterations found in human tumors. In this issue of Cancer Cell, test a novel signaling inhibitor in a genetically defined mouse medulloblastoma and show the utility of these models in drug development. They demonstrate that targeting signaling components downstream of tumor initiating mutations can be an effective therapeutic strategy for solid tumors.
通过体细胞或种系基因改造策略生成的组织学精确的人类癌症小鼠模型，概括了人类肿瘤中发现的基因改变。在本期《癌细胞》杂志中，他们在一种基因明确的小鼠髓母细胞瘤中测试了一种新型信号抑制剂，并展示了这些模型在药物开发中的效用。他们证明，靶向肿瘤起始突变下游的信号成分可能是实体瘤的一种有效治疗策略。
