Lhermitte-Duclos病的功能成像
Functional imaging in Lhermitte-Duclose disease.
作者信息
Padma Madakasira V, Jacobs Martin, Sequeira Pam, Adineh Mehdi, Satter Martin, Kraus Gary, Mantil Joseph C
机构信息
Wallace-Kettering Neurosciences Institute, Kettering Medical Center, OH 45429, USA.
出版信息
Mol Imaging Biol. 2004 Sep-Oct;6(5):319-23. doi: 10.1016/j.mibio.2004.06.005.
PURPOSE
A comprehensive metabolic characterization of a patient with dysplastic gangliocytoma of the cerebellum or Lhermitte-Duclos Disease (LDD) is presented.
PROCEDURES
Assessment using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), carbon-11-labeled methionine (11C-MET), carbon-11-labeled choline (11C-Choline) positron emission tomography (PET), and 1H-proton magnetic resonance spectroscopy (MRS) was carried out in a 30-year-old Caucasian woman.
RESULTS
FDG-PET revealed hypermetabolism of the tumor. 11C-MET-PET revealed moderate uptake and 11C-Choline showed no uptake. 1H-MRS demonstrated an elevated level of lactate and decreased levels of choline (Cho) and myoinositol.
CONCLUSION
Functional imaging in LDD reflects the dual pathological features of neoplasm and hamartoma.
目的
对一名患有小脑发育异常性神经节细胞瘤或勒米特-迪克洛病（LDD）的患者进行全面的代谢特征分析。
程序
对一名30岁的白种女性进行了使用2-脱氧-2-[18F]氟-D-葡萄糖（FDG）、碳-11标记的蛋氨酸（11C-MET）、碳-11标记的胆碱（11C-胆碱）正电子发射断层扫描（PET）以及1H-质子磁共振波谱（MRS）的评估。
结果
FDG-PET显示肿瘤代谢增高。11C-MET-PET显示摄取中等，而11C-胆碱未显示摄取。1H-MRS显示乳酸水平升高，胆碱（Cho）和肌醇水平降低。
结论
LDD中的功能成像反映了肿瘤和错构瘤的双重病理特征。
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