Anderson Gregory G, Martin Steven M, Hultgren Scott J
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8230, St. Louis, MO 63110, USA.
Microbes Infect. 2004 Oct;6(12):1094-101. doi: 10.1016/j.micinf.2004.05.023.
Urinary tract infections pose a serious health threat with respect to antibiotic resistance and high recurrence rates. While the host robustly responds to bacterial infiltration into the bladder, uropathogenic Escherichia coli can survive the onslaught to persist for months after initially infecting. To accomplish this feat, uropathogenic E. coli forms intracellular bacterial communities, with many biofilm-like properties, within the bladder epithelium. These communities may allow bacteria to subvert host defenses and form a persistent reservoir in the bladder.
尿路感染在抗生素耐药性和高复发率方面构成严重的健康威胁。虽然宿主对细菌侵入膀胱会做出强烈反应，但尿路致病性大肠杆菌能够在最初感染后抵御攻击并持续存活数月。为了实现这一壮举，尿路致病性大肠杆菌在膀胱上皮细胞内形成具有许多生物膜样特性的细胞内细菌群落。这些群落可能使细菌能够颠覆宿主防御并在膀胱中形成一个持续的储存库。
