Wegner K Mathias, Kalbe Martin, Schaschl Helmut, Reusch Thorsten B H
Department of Evolutionary Ecology, Max Planck Institute of Limnology, August-Thienemann-Street 2, 24306 Plön, Germany.
Microbes Infect. 2004 Oct;6(12):1110-6. doi: 10.1016/j.micinf.2004.05.025.
Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges.
超显性选择或杂合子优势可以部分解释在经典主要组织相容性复合体（MHC）位点发现的异常多态性。然而，几项仅使用单一感染因子的研究往往未能检测到它。在这里，我们回顾了最近的研究，这些研究表明，由于MHC介导的抗性具有显性性质，杂合子优势最有可能在多种病原体攻击中被检测到。
