Rodríguez Y, Giri M, Rottiers R, Christophe A B
Department of Endocrinology and Metabolic Diseases, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Prostaglandins Leukot Essent Fatty Acids. 2004 Nov;71(5):303-8. doi: 10.1016/j.plefa.2004.04.004.
There exist controversial reports regarding the differences in phospholipid fatty acids in type 2 diabetic and obese patients as compared to controls. The study was aimed at assessing the combined effect of type 2 diabetes and obesity on the fatty acid composition of plasma phospholipids. The experimental group consisted of 23 Belgian obese type 2 diabetics on Metformin. Two control groups were used: healthy lean and obese individuals in the same BMI range as the diabetics. Plasma phospholipids were isolated and their fatty acids and vinyl ether moieties were determined. Significance was set at P < 0.01. Plasma phospholipid fatty acids and plasmalogen-derived dimethyl acetals in diabetics deviated in many respects from these of lean controls but were not significantly different from those of obese non-diabetic patients. Therefore, the deviations of the fatty acid pattern of plasma phospholipids in type 2 diabetes may be attributed to obesity rather than to diabetes itself.
关于2型糖尿病患者和肥胖患者与对照组相比磷脂脂肪酸的差异，存在有争议的报道。本研究旨在评估2型糖尿病和肥胖对血浆磷脂脂肪酸组成的联合影响。实验组由23名服用二甲双胍的比利时肥胖2型糖尿病患者组成。使用了两个对照组：与糖尿病患者BMI范围相同的健康瘦人和肥胖个体。分离血浆磷脂并测定其脂肪酸和乙烯基醚部分。显著性设定为P < 0.01。糖尿病患者血浆磷脂脂肪酸和缩醛磷脂衍生的二甲基缩醛在许多方面与瘦对照组不同，但与肥胖非糖尿病患者无显著差异。因此，2型糖尿病患者血浆磷脂脂肪酸模式的偏差可能归因于肥胖而非糖尿病本身。
