Hulsewé Karel W E, van Acker Bernadette A C, Hameeteman Wim, van der Hulst Rene R W J, Vainas Tryfon, Arends Jan-Willem, van Kreel Bernard K, von Meyenfeldt Maarten F, Soeters Peter B
Department of General Surgery, University Hospital Maastricht, The Netherlands.
Clin Nutr. 2004 Oct;23(5):1217-25. doi: 10.1016/j.clnu.2004.04.002.
Nutritional depletion has been related to low glutamine levels in plasma and gut mucosa. This study was set up to investigate the effects of glutamine-enriched total parenteral nutrition on intestinal morphology and permeability.
Twenty-three depleted patients were randomized and after stabilization baseline measurements were performed. Plasma glutamine concentrations, gut morphology (including proliferation and lymphocyte markers) and intestinal permeability were measured. After administration during 8-10 days of a glutamine enriched total parenteral nutrition or an isonitrogenous control solution the measurements were repeated.
No significant changes in glutamine concentrations, intestinal permeability, mucosal morphology or gut mucosal inflammation were observed between groups.
Glutamine enriched total parenteral nutrition in a depleted patient population does not result in improvements in gut morphology and gut barrier function.
营养消耗与血浆和肠黏膜中谷氨酰胺水平降低有关。本研究旨在探讨富含谷氨酰胺的全肠外营养对肠道形态和通透性的影响。
23例营养消耗患者被随机分组，在病情稳定后进行基线测量。测量血浆谷氨酰胺浓度、肠道形态（包括增殖和淋巴细胞标志物）和肠道通透性。在给予富含谷氨酰胺的全肠外营养或等氮对照溶液8 - 10天后，重复进行测量。
两组之间在谷氨酰胺浓度、肠道通透性、黏膜形态或肠黏膜炎症方面未观察到显著变化。
在营养消耗患者群体中，富含谷氨酰胺的全肠外营养并不能改善肠道形态和肠道屏障功能。
