Kyle Ursula G, Bosaeus Ingvar, De Lorenzo Antonio D, Deurenberg Paul, Elia Marinos, Gómez José Manuel, Heitmann Berit Lilienthal, Kent-Smith Luisa, Melchior Jean-Claude, Pirlich Matthias, Scharfetter Hermann, Schols Annemie M W J, Pichard Claude
Geneva University Hospital, Switzerland.
Clin Nutr. 2004 Oct;23(5):1226-43. doi: 10.1016/j.clnu.2004.06.004.
The use of bioelectrical impedance analysis (BIA) is widespread both in healthy subjects and patients, but suffers from a lack of standardized method and quality control procedures. BIA allows the determination of the fat-free mass (FFM) and total body water (TBW) in subjects without significant fluid and electrolyte abnormalities, when using appropriate population, age or pathology-specific BIA equations and established procedures. Published BIA equations validated against a reference method in a sufficiently large number of subjects are presented and ranked according to the standard error of the estimate. The determination of changes in body cell mass (BCM), extra cellular (ECW) and intra cellular water (ICW) requires further research using a valid model that guarantees that ECW changes do not corrupt the ICW. The use of segmental-BIA, multifrequency BIA, or bioelectrical spectroscopy in altered hydration states also requires further research. ESPEN guidelines for the clinical use of BIA measurements are described in a paper to appear soon in Clinical Nutrition.
生物电阻抗分析（BIA）在健康受试者和患者中都有广泛应用，但缺乏标准化方法和质量控制程序。当使用适当的针对人群、年龄或特定病理的BIA方程及既定程序时，BIA可用于测定无明显液体和电解质异常的受试者的去脂体重（FFM）和总体水（TBW）。本文给出了经大量受试者验证且与参考方法对比的已发表BIA方程，并根据估计标准误差进行排序。使用有效模型来确定体细胞质量（BCM）、细胞外液（ECW）和细胞内液（ICW）的变化，这需要进一步研究以确保ECW变化不会影响ICW。在水合状态改变时使用节段性BIA、多频BIA或生物电阻抗光谱法也需要进一步研究。ESPEN关于BIA测量临床应用的指南将在近期发表于《临床营养》杂志的一篇论文中进行描述。
