Fliegel Larry
Canadian Institute of Health Research Membrane Protein Research Group and the Department of Biochemistry, University of Alberta, Edmonton, Alta, T6G 2H7, Canada.
Int J Biochem Cell Biol. 2005 Jan;37(1):33-7. doi: 10.1016/j.biocel.2004.02.006.
The Na+/H+ exchanger (NHE) isoform 1 is a ubiquitously expressed integral membrane protein which regulates intracellular pH in mammalian cells. Nine isoforms of the Na+/H+ exchanger have been identified. The isoform first discovered has two domains: an N-terminal membrane domain containing approximately 500 amino acids and a C-terminal regulatory domain containing approximately 315 amino acids. The exchanger, which resides in the plasma membrane, exchanges an intracellular proton for an extracellular sodium, thereby regulating intracellular pH. It is involved in cell growth and differentiation, cell migration, and regulation of sodium fluxes. The Na+/H+ exchanger plays an important role in myocardial damage during ischemia and reperfusion and has recently been implicated as a mediator of cardiac hypertrophy. Inhibitors of the Na+/H+ exchanger, which may prove useful in the clinical treatment of these conditions, are currently being developed and clinical trials are underway.
钠氢交换体（NHE）同工型1是一种广泛表达的整合膜蛋白，可调节哺乳动物细胞内的pH值。现已鉴定出9种钠氢交换体同工型。最早发现的同工型有两个结构域：一个包含约500个氨基酸的N端膜结构域和一个包含约315个氨基酸的C端调节结构域。该交换体位于质膜中，将细胞内的质子与细胞外的钠离子进行交换，从而调节细胞内pH值。它参与细胞生长和分化、细胞迁移以及钠通量的调节。钠氢交换体在缺血和再灌注期间的心肌损伤中起重要作用，最近被认为是心肌肥大的介质。目前正在开发可能对这些病症的临床治疗有用的钠氢交换体抑制剂，并且正在进行临床试验。
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