Odunewu-Aderibigbe Ayodeji, Fliegel Larry
Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
IUBMB Life. 2014 Oct;66(10):679-85. doi: 10.1002/iub.1323. Epub 2014 Oct 30.
The mammalian Na(+) /H(+) exchanger isoform 1 (NHE1) is an integral membrane protein ubiquitously expressed in mammalian cells. It is made up of two domains: a 500-amino acid membrane domain that is responsible for transport and removes protons, and a regulatory intracellular cytosolic domain made up of 315 amino acids. NHE1 is the major isoform found in the myocardium where it plays an important role in the regulation of intracellular pH by exchanging one intracellular proton for one extracellular sodium. Although NHE1 normally fulfills this important physiological role, aberrant regulation and overactivation of NHE1 contribute to heart disease, including acute ischemia reperfusion damage and cardiac hypertrophy. This review summarizes past and current knowledge of the role and regulation of NHE1 in the myocardium.
哺乳动物钠氢交换体同工型1（NHE1）是一种整合膜蛋白，在哺乳动物细胞中普遍表达。它由两个结构域组成：一个由500个氨基酸组成的膜结构域，负责转运并移除质子；另一个是由315个氨基酸组成的调节性细胞内胞质结构域。NHE1是心肌中发现的主要同工型，它通过将一个细胞内质子与一个细胞外钠离子交换，在调节细胞内pH值方面发挥重要作用。尽管NHE1通常履行这一重要的生理功能，但NHE1的异常调节和过度激活会导致心脏病，包括急性缺血再灌注损伤和心肌肥大。本综述总结了过去和当前关于NHE1在心肌中的作用和调节的知识。
