Tucci Sonia A, Rogers Elizabeth K, Korbonits Marta, Kirkham Tim C
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA.
Br J Pharmacol. 2004 Nov;143(5):520-3. doi: 10.1038/sj.bjp.0705968. Epub 2004 Sep 20.
The paraventricular nucleus (PVN) of the hypothalamus plays a key role in the control of appetite and energy balance. Both ghrelin and cannabinoid receptor agonists increase food intake when administered into this nucleus: this study investigated possible interactions between the two systems in relation to eating. The orexigenic effect of ghrelin (100 pmol) when infused in to the PVN was reversed by a small, systemic dose of the CB(1) cannabinoid receptor antagonist SR141716 (1 mg kg(-1)). This is the first demonstration of a functional relationship between brain ghrelin and endocannabinoid systems, and, although it needs to be further investigated, the effect of ghrelin on food intake when injected into the PVN seems to be mediated by stimulation of cannabinoid release.
下丘脑室旁核(PVN)在食欲和能量平衡的控制中起关键作用。将胃饥饿素和大麻素受体激动剂注入该核团时均会增加食物摄入量:本研究调查了这两个系统在进食方面可能存在的相互作用。当向PVN注入胃饥饿素(100皮摩尔)时,其促食欲作用可被小剂量全身性给予的CB(1)大麻素受体拮抗剂SR141716(1毫克/千克)逆转。这首次证明了脑内胃饥饿素系统与内源性大麻素系统之间存在功能关系,并且,尽管还需要进一步研究,但注入PVN的胃饥饿素对食物摄入的影响似乎是通过刺激大麻素释放介导的。