Department of Nutritional Sciences, University of Georgia, Athens, Georgia, USA.
Pharmacol Res Perspect. 2024 Oct;12(5):e1251. doi: 10.1002/prp2.1251.
In parallel to the legalization of cannabis for both medicinal and recreational purposes, cannabinoid use has steadily increased over the last decade in the United States. Cannabinoids, such as tetrahydrocannabinol and anandamide, bind to the central cannabinoid-1 (CB1) receptor to impact several physiological processes relevant for body weight regulation, including appetite and energy expenditure. The hypothalamus integrates peripheral signals related to energy balance, houses several nuclei that orchestrate eating, and expresses the CB1 receptor. Herein we review literature to date concerning cannabinergic action in the hypothalamus with a specific focus on eating behaviors. We highlight hypothalamic areas wherein researchers have focused their attention, including the lateral, arcuate, paraventricular, and ventromedial hypothalamic nuclei, and interactions with the hormone leptin. This review serves as a comprehensive analysis of what is known about cannabinoid signaling in the hypothalamus, highlights gaps in the literature, and suggests future directions.
随着大麻在医学和娱乐方面合法化，在美国，大麻素的使用在过去十年中稳步增加。大麻素，如四氢大麻酚和花生四烯酸酰胺，与中央大麻素-1（CB1）受体结合，影响与体重调节相关的几个生理过程，包括食欲和能量消耗。下丘脑整合与能量平衡相关的外周信号，拥有几个协调进食的核，并表达 CB1 受体。本文综述了迄今为止关于大麻素在下丘脑的作用的文献，特别关注进食行为。我们强调了研究人员关注的下丘脑区域，包括外侧、弓状、室旁和腹内侧下丘脑核，以及与激素瘦素的相互作用。本综述全面分析了已知的大麻素在下丘脑的信号传递，突出了文献中的空白，并提出了未来的方向。
