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用于动态记录睡眠呼吸暂停的外周动脉张力测量法、血氧测定法和活动记录仪

Peripheral arterial tonometry, oximetry and actigraphy for ambulatory recording of sleep apnea.

作者信息

Penzel Thomas, Kesper Karl, Pinnow Iris, Becker Heinrich F, Vogelmeier Claus

机构信息

Division for Pulmonary Diseases, Department of Internal Medicine, Hospital of Philipps-University, Baldingerstr. 1, D-35033 Marburg, Germany.

出版信息

Physiol Meas. 2004 Aug;25(4):1025-36. doi: 10.1088/0967-3334/25/4/019.

Abstract

Autonomous nervous functions change with sleep stages and show characteristic changes associated with sleep disorders. Therefore, continuous monitoring of autonomous nervous functions during sleep can be used for diagnostic purposes. Recently, the peripheral arterial tonometry (PAT) has been introduced to determine peripheral arterial vascular tone on the finger being determined by sympathetic activity. We investigate a new ambulatory recording system which uses PAT, oximetry and actigraphy (Watch-PAT) in order to detect sleep apnea and arousal. The Watch-PAT is battery operated and attached to the wrist and has two finger sensors. Twenty-one patients with suspected sleep apnea were recorded with cardiorespiratory polysomnography and the new system in parallel. Seventeen recordings could be evaluated. The correlation for the apnea/hypopnea index derived from the sleep laboratory and the respiratory disturbance index derived from the Watch-PAT was r = 0.89 (p < 0.01) and between arousals and the respiratory disturbance index was r = 0.77 (p < 0.01). The correlation for the total sleep time compared between the two systems was r = 0.15 (n.s.). The Watch-PAT detects apneas and hypopneas with a reasonable reliability and it is very sensitive to arousals. The number of Watch-PAT events lies between the sum of apneas plus hypopneas and arousals. Arousals are not unique to apnea events and therefore the specifity of the Watch-PAT is limited. In conclusion, the Watch-PAT is well suited to perform therapy control studies in patients suffering from sleep apnea and being treated.

摘要

自主神经功能随睡眠阶段而变化,并呈现出与睡眠障碍相关的特征性变化。因此,睡眠期间对自主神经功能的持续监测可用于诊断目的。最近,外周动脉张力测定法(PAT)已被用于确定由交感神经活动决定的手指外周动脉血管张力。我们研究了一种新的动态记录系统,该系统使用PAT、血氧饱和度测定法和活动记录仪(Watch-PAT)来检测睡眠呼吸暂停和觉醒。Watch-PAT由电池供电,佩戴在手腕上,有两个手指传感器。对21名疑似睡眠呼吸暂停的患者同时进行了心肺多导睡眠图和新系统的记录。17份记录可供评估。睡眠实验室得出的呼吸暂停/低通气指数与Watch-PAT得出的呼吸紊乱指数之间的相关性为r = 0.89(p < 0.01),觉醒与呼吸紊乱指数之间的相关性为r = 0.77(p < 0.01)。两个系统之间总睡眠时间的相关性为r = 0.15(无统计学意义)。Watch-PAT检测呼吸暂停和低通气具有合理的可靠性,并且对觉醒非常敏感。Watch-PAT事件的数量介于呼吸暂停加低通气的总和与觉醒之间。觉醒并非呼吸暂停事件所特有,因此Watch-PAT的特异性有限。总之,Watch-PAT非常适合对患有睡眠呼吸暂停并正在接受治疗的患者进行治疗控制研究。

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