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肠道和肠外致病性大肠杆菌菌株对脱氧核糖的利用:一种与竞争力相关的代谢适应。

Use of deoxyribose by intestinal and extraintestinal pathogenic Escherichia coli strains: a metabolic adaptation involved in competitiveness.

作者信息

Bernier-Fébreau Christine, du Merle Laurence, Turlin Evelyne, Labas Valérie, Ordonez Juana, Gilles Anne-Marie, Le Bouguénec Chantal

机构信息

Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France.

出版信息

Infect Immun. 2004 Oct;72(10):6151-6. doi: 10.1128/IAI.72.10.6151-6156.2004.

Abstract

We showed that the deoK operon, which confers the ability to use deoxyribose as a carbon source, is more common among pathogenic than commensal Escherichia coli strains. The expression of the deoK operon increases the competitiveness of clinical isolates, suggesting that this biochemical characteristic plays a role in host infectivity.

摘要

我们发现,赋予利用脱氧核糖作为碳源能力的deoK操纵子在致病性大肠杆菌菌株中比共生大肠杆菌菌株中更为常见。deoK操纵子的表达增强了临床分离株的竞争力,这表明这种生化特性在宿主感染性中发挥作用。

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