用约氏疟原虫裂殖子表面蛋白1和4/5的组合进行口服免疫可增强对致命性疟疾攻击的保护作用。
Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge.
作者信息
Wang Lina, Goschnick Matthew W, Coppel Ross L
机构信息
Department of Microbiology, Monash University, Clayton, Victoria, Australia.
出版信息
Infect Immun. 2004 Oct;72(10):6172-5. doi: 10.1128/IAI.72.10.6172-6175.2004.
Abstract
Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection. A combination of these two proteins administered orally conferred improved protection compared to that conferred by either protein administered alone.
摘要
用大肠杆菌表达的约氏疟原虫裂殖子表面蛋白4/5或裂殖子表面蛋白1的C端19 kDa片段对小鼠进行口服免疫，可诱导全身抗体反应，并保护小鼠免受致命的疟疾感染。与单独给予这两种蛋白质中的任何一种相比，口服给予这两种蛋白质的组合可提供更好的保护。
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