Good M F, Doolan D L
The Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital 4029, Queensland, Australia.
Curr Opin Immunol. 1999 Aug;11(4):412-9. doi: 10.1016/S0952-7915(99)80069-7.
Malaria, a disease responsible for immense human suffering, is caused by infection with Plasmodium spp. parasites, which have a very complex life cycle - antigenically unique stages infect different tissues of the body. This review details recent developments in our understanding of immunity both to pre-erythrocytic stage antigens and to erythrocytic stage antigens. The former is largely mediated via CD8(+) T cells and involves IFN-gamma, nitric oxide, IL-12 and natural killer cells; the latter varies (in different hosts and with different parasites) but is largely mediated by antibody, helper T cells, nitric oxide and gammadelta T cells. The recent progress towards clinical trials of vaccine candidates against both the pre-erythrocytic stage and erythrocytic stage is also summarized, in particular the use of heterologous prime/boost strategies for the former and the use of MSP1 as a candidate vaccine for the latter.
疟疾是一种给人类带来巨大痛苦的疾病，由感染疟原虫属寄生虫引起，这些寄生虫具有非常复杂的生命周期——抗原性独特的阶段会感染身体的不同组织。本综述详细介绍了我们在对红细胞前期抗原和红细胞期抗原免疫理解方面的最新进展。前者主要由CD8(+) T细胞介导，涉及干扰素-γ、一氧化氮、白细胞介素-12和自然杀伤细胞；后者则有所不同（在不同宿主和不同寄生虫中），但主要由抗体、辅助性T细胞、一氧化氮和γδ T细胞介导。还总结了针对红细胞前期和红细胞期的候选疫苗临床试验的最新进展，特别是前者使用的异源初免/加强策略以及后者使用MSP1作为候选疫苗的情况。
