Park Eun Joo, Kim Mi Hee, Kim Dae Young
Department of Chemistry, Soonchunhyang University, Asan P.O. Box 97, Chungnam 336-600, Korea.
J Org Chem. 2004 Oct 1;69(20):6897-9. doi: 10.1021/jo0401772.
Catalytic enantioselective alkylation promoted by a quaternary ammonium salt from cinchonine as a phase transfer catalyst is described. Treatment of cyclo beta-keto esters with alkyl halide under mild reaction conditions afforded the corresponding alpha-alkylated beta-keto esters in moderate to excellent yields with high enantiomeric excesses
描述了由金鸡宁季铵盐作为相转移催化剂促进的催化对映选择性烷基化反应。在温和的反应条件下，用卤代烷处理环β-酮酯，以中等到优异的产率和高对映体过量得到相应的α-烷基化β-酮酯。
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