神经节苷脂复合物作为吉兰-巴雷综合征新的靶抗原

Ganglioside complexes as new target antigens in Guillain-Barré syndrome.

作者信息

Kaida Ken-ichi, Morita Daiji, Kanzaki Mami, Kamakura Keiko, Motoyoshi Kazuo, Hirakawa Minako, Kusunoki Susumu

机构信息

Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.

出版信息

Ann Neurol. 2004 Oct;56(4):567-71. doi: 10.1002/ana.20222.

DOI:10.1002/ana.20222

PMID:15389898

Abstract

Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain-Barre syndrome (GBS) by the use of enzyme-linked immunosorbent assay and thin-layer chromatogram immunostaining. Those sera also had antibody activities to such ganglioside complexes as GD1a/GM1, GD1b/GT1b, and GM1/GT1b but had little or no reactivity to the each isolated antigen. Clustered epitopes of the ganglioside complex in the plasma membrane may be targeted by such an antibody, and interaction between the antibody and ganglioside complex may induce the neuropathy.

摘要

通过酶联免疫吸附测定和薄层色谱免疫染色法，在100例格林-巴利综合征（GBS）患者中的8例血清中发现了对神经节苷脂GD1a和GD1b复合物（GD1a/GD1b）具有特异性的抗体。这些血清对GD1a/GM1、GD1b/GT1b和GM1/GT1b等神经节苷脂复合物也具有抗体活性，但对每种分离的抗原几乎没有或没有反应性。质膜中神经节苷脂复合物的聚集表位可能是这种抗体的靶标，并且抗体与神经节苷脂复合物之间的相互作用可能诱发神经病变。