EAGLE H
J Exp Med. 1949 Dec;90(6):595-607. doi: 10.1084/jem.90.6.595.
The amount of penicillin which suffices to abort pneumococcal and streptococcal infections in white mice and rabbits, as well as syphilitic infection in rabbits, has been shown to increase markedly with the number of organisms inoculated. The curative dose increases also with the age of the infection, presumably owing to the interim increase in the number of organisms in the nfected host. The necessity for the larger doses of penicillin is attributed to the longer itime for which effectively bactericidal concentrations of penicillin must then be provided in order to kill the larger number of organisms.
已表明,足以使小白鼠和兔子的肺炎球菌及链球菌感染以及兔子的梅毒感染中止的青霉素量,会随着接种的生物体数量显著增加。治疗剂量也会随着感染时间的延长而增加,大概是由于受感染宿主体内生物体数量在此期间增加。需要更大剂量的青霉素是因为必须提供有效杀菌浓度的青霉素的时间更长,以便杀死更多的生物体。