年轻和成熟雄性费希尔大鼠心肌肌动球蛋白ATP酶的钙敏感性。简要说明。

Calcium sensitivity of myocardial actomyosin ATPase in young and mature male Fischer rats. A brief note.

作者信息

Rockstein M, Chesky J A, Lopez T

出版信息

Mech Ageing Dev. 1978 Dec;8(6):413-6. doi: 10.1016/0047-6374(78)90040-4.

Abstract

Although myocardial actomyosin ATPase specific activity determined at Ca2+ levels of 1 x 10(-3) to 1 x 10(-2) M is consistently higher in two-month old male Fischer rats than in twelve-month old individuals, this difference can be eliminated if the enzyme is assayed at lower calcium concentrations. This suggests that the previously reported, declining actomyosin ATPase activity in the rat myocardium with advancing age may represent an age-related diminished ability of calcium to reverse the known inhibition upon actomyosin ATPase by the regulatory proteins.

摘要

尽管在1×10⁻³至1×10⁻²M的Ca²⁺水平下测定的心肌肌动球蛋白ATP酶比活性在两个月大的雄性Fischer大鼠中始终高于十二个月大的个体，但如果在较低钙浓度下测定该酶，则这种差异可以消除。这表明先前报道的随着年龄增长大鼠心肌中肌动球蛋白ATP酶活性下降可能代表与年龄相关的钙逆转调节蛋白对肌动球蛋白ATP酶已知抑制作用的能力减弱。