视网膜脱离和增殖性玻璃体视网膜病变后玻璃体对人巩膜成纤维细胞的趋化活性。
The chemoattractant activity of the vitreous to human scleral fibroblasts following retinal detachment and proliferative vitreoretinopathy.
作者信息
Wilson-Holt N, Khaw P, Savage F, Grierson I
机构信息
Moorfields Eye Hospital, London.
出版信息
Br J Ophthalmol. 1992 Mar;76(3):159-62. doi: 10.1136/bjo.76.3.159.
The results are presented of a migration assay of scleral fibroblasts to 25% diluted vitreous samples from 27 patients with complex retinal detachments divided into three groups: group 1, no proliferative vitreoretinopathy (PVR); group 2, early PVR; and group 3, advanced PVR. There was a statistically significantly greater migration with vitreous samples from group 3 than with group 1 (p less than 0.0001) but no significant correlation for migration with the age of patients, duration of retinal detachment, or number of retinal procedures undertaken. Analysis of vitreous by gel electrophoresis showed that cellular migration was proportional to the number of peptide bands. Vitreous fibronectin levels were measured and there was a positive correlation between fibronectin in the vitreous samples and the migration of fibroblasts to the vitreous (r = 0.68, p less than 0.004).
本文呈现了对27例复杂性视网膜脱离患者的巩膜成纤维细胞向25%稀释玻璃体样本迁移的检测结果。这些患者被分为三组：第1组，无增殖性玻璃体视网膜病变（PVR）；第2组，早期PVR；第3组，晚期PVR。与第1组的玻璃体样本相比，第3组的玻璃体样本导致的细胞迁移在统计学上显著更多（p小于0.0001），但细胞迁移与患者年龄、视网膜脱离持续时间或所进行的视网膜手术次数之间无显著相关性。通过凝胶电泳对玻璃体进行分析表明，细胞迁移与肽带数量成正比。测量了玻璃体纤连蛋白水平，玻璃体样本中的纤连蛋白与成纤维细胞向玻璃体的迁移之间存在正相关（r = 0.68，p小于0.004）。
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