Campochiaro P A, Jerdan J A, Glaser B M, Cardin A, Michels R G
Arch Ophthalmol. 1985 Sep;103(9):1403-5. doi: 10.1001/archopht.1985.01050090155053.
Several studies have focused on retinal pigment epithelial (RPE) cell proliferation as an important event in proliferative vitreoretinopathy (PVR). Little attention has been given to the question of how RPE cells gain access to the vitreous cavity where proliferation occurs. We have recently demonstrated that the serum components fibronectin and platelet-derived growth factor stimulate and direct RPE migration in vitro. In this study, we used this same in vitro technique to examine vitreous aspirates from 13 eyes with PVR, five eyes with macular puckers, and three eyes with uncomplicated retinal detachments for their ability to stimulate RPE migration. We found that aspirates from eyes with PVR stimulated RPE migration to a much greater extent than aspirates from eyes with macular pucker and uncomplicated retinal detachments. The ability to stimulate RPE cell migration correlated with high levels (mean +/- SEM, 178 +/- 67 mg/L) of immunoreactive fibronectin.
多项研究聚焦于视网膜色素上皮（RPE）细胞增殖，将其视为增殖性玻璃体视网膜病变（PVR）中的一个重要事件。然而，对于RPE细胞如何进入发生增殖的玻璃体腔这一问题，却鲜有关注。我们最近证实，血清成分纤连蛋白和血小板衍生生长因子在体外可刺激并引导RPE迁移。在本研究中，我们采用同样的体外技术，检测了13例PVR患眼、5例黄斑皱襞患眼和3例单纯性视网膜脱离患眼的玻璃体吸出物刺激RPE迁移的能力。我们发现，PVR患眼的吸出物刺激RPE迁移的程度远大于黄斑皱襞患眼和单纯性视网膜脱离患眼的吸出物。刺激RPE细胞迁移的能力与高水平（平均±标准误，178±67 mg/L）的免疫反应性纤连蛋白相关。
