Ito H, Suzuki F, Yamaguchi K, Nishikawa Y, Kotake T
Department of Urology, Teikyo University School of Medicine, Ichihara Hospital, Japan.
Clin Nephrol. 1992 Jan;37(1):14-8.
Oxalic acid seems to play a far greater role in the formation of calcium oxalate stone than calcium. Three grams of calcium lactate and 3 g of sodium potassium citrate were administered to 46 urolithiasis patients, whose stones were mainly composed of calcium oxalate. Urinary oxalate level was reduced significantly without raising urinary calcium level by the administration of the two drugs for two weeks. The reduction of urinary oxalic acid was particularly remarkable in patients without hypercalciuria. The mechanism of action of these drugs was discussed.
草酸在草酸钙结石形成过程中似乎比钙发挥着更为重要的作用。对46例主要为草酸钙结石的尿石症患者给予3克乳酸钙和3克柠檬酸钾钠。连续两周给予这两种药物后，尿草酸水平显著降低，而尿钙水平未升高。在无高钙尿症的患者中，尿草酸的降低尤为显著。对这些药物的作用机制进行了讨论。
