Saenghirunvattana S, Sermswan A, Piratchvej V, Rochanawutanon M, Kaojarern S, Rattananenya T
Pulmonary unit, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Chest. 1992 Mar;101(3):833-5. doi: 10.1378/chest.101.3.833.
To determine the effect of lung irradiation in mice with paraquat poisoning and whether irradiation could prevent lung destruction, we found the the lethal dose for 50 percent survival (LD50) in 50 mice (Swiss strain) was 25 mg/kg of body weight. The first control group comprised 15 mice and their lungs were irradiated with 200 rad for seven days. There was no death within six weeks. The lungs at autopsy appeared mildly congested. The control group comprised 15 mice. They were injected with 25 mg/kg of paraquat. Six died within three days. The experimental group included 14 mice injected with paraquat and with lung irradiation. Eight died within three days (p greater than 0.5). The pathologic findings in the experimental group revealed lung congestion and fibrosis that was more pronounced than in the group that received only paraquat. We conclude that radiotherapy is not effective in amelioration of paraquat-induced lung damage in mice.
为了确定肺部照射对百草枯中毒小鼠的影响以及照射是否能预防肺部损伤，我们发现50只（瑞士品系）小鼠的半数致死剂量（LD50）为25毫克/千克体重。第一个对照组由15只小鼠组成，其肺部接受200拉德照射，持续7天。六周内无死亡。尸检时肺部轻度充血。对照组由15只小鼠组成。它们被注射25毫克/千克的百草枯。三天内有6只死亡。实验组包括14只注射百草枯并接受肺部照射的小鼠。三天内有8只死亡（p大于0.5）。实验组的病理结果显示肺部充血和纤维化比仅接受百草枯处理的组更明显。我们得出结论，放射治疗对改善小鼠百草枯诱导的肺损伤无效。
