Kalfarentzos F, Spiliotis J, Chalmoukis A, Vagenas C, Vagenakis A
Department of Surgery, School of Medicine, University of Patras, Greece.
J Am Coll Nutr. 1992 Feb;11(1):17-20. doi: 10.1080/07315724.1992.10718190.
Total parenteral nutrition (TPN) induces biliary dilatation, sludge and formation of gallstones. Cholecystokinin (CCK) induces gallbladder (GB) contraction. During thyrotropin-releasing hormone (TRH) testing for thyroid function, we observed that patients felt a strong micturition reflex attributable to smooth muscle contraction of the bladder. The possibility of GB contraction after TRH administration was studied compared to cholecystokinin-octapeptide (CCK-OP) and/or fatty meal administration. The effect of intravenous (IV) CCK-OP, TRH and a combination of the two on GB volume was studied in normal volunteers without GB or liver disease and in patients receiving TPN for greater than 2 weeks. Subjects included six normal volunteers who received an oral fatty meal only, 18 other normal volunteers (Group A) and 18 TPN patients (Group B). Gallbladder contraction was estimated by ultrasound prior to and after administration of the fatty meal; in the other 36 subjects, GB contraction was calculated prior to and after administration of CCK-OP, TRH, or both. Results are expressed as a percentage of the GB basal volume using each subject as his or her own control. Group A and Group B were each divided into three equal subgroups receiving IV CCK-OP (A1, B1), TRH (A2, B2), or both (A3, B3).(ABSTRACT TRUNCATED AT 250 WORDS)
全胃肠外营养（TPN）可导致胆管扩张、胆泥形成及胆结石。胆囊收缩素（CCK）可引起胆囊（GB）收缩。在进行促甲状腺激素释放激素（TRH）甲状腺功能试验期间，我们观察到患者因膀胱平滑肌收缩而出现强烈的排尿反射。将TRH给药后GB收缩的可能性与胆囊收缩素八肽（CCK-OP）和/或脂肪餐给药进行了比较研究。在无GB或肝脏疾病的正常志愿者以及接受TPN超过2周的患者中，研究了静脉注射（IV）CCK-OP、TRH以及两者联合使用对GB体积的影响。受试者包括仅接受口服脂肪餐的6名正常志愿者、另外18名正常志愿者（A组）和18名TPN患者（B组）。在给予脂肪餐之前和之后通过超声估计胆囊收缩情况；在其他36名受试者中，在给予CCK-OP、TRH或两者之前和之后计算GB收缩情况。结果以每个受试者自身为对照，以GB基础体积的百分比表示。A组和B组各自分为三个相等的亚组，分别接受静脉注射CCK-OP（A1、B1）、TRH（A2、B2）或两者（A3、B3）。（摘要截短于250字）
