Sakumoto K
Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, Okinawa.
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Jan;44(1):91-6.
To improve the cure rate for locally advanced cervical cancer, intra-arterial infusion chemotherapy with cisplatin (I-A chemotherapy) was performed before starting radiation therapy. Twenty-five patients, having a large central tumor (over 5 cm in antero-posterior diameter by CT scan), were treated by I-A chemotherapy. The catheter was inserted selectively into the uterine artery. The dose of cisplatin was 120 mg/m2. After the chemotherapy, all the patients were treated by radiation therapy. Eighteen of 25 patients treated with I-A chemotherapy were evaluable. Seven patients (38.8%) experienced partial tumor regression (greater than 50% reduction in the measured diameter). The survival rate (Kaplan-Meier Method) for combined therapy with I-A chemotherapy and radiotherapy was significantly higher than that for 23 patients treated by conventional radiation therapy alone. The toxicity of I-A chemotherapy was similar to that of systemic administration. There were three catheter complications. Intra-arterial chemotherapy with cisplatin followed by radiation therapy is effective for advanced uterine cervical cancer.
为提高局部晚期宫颈癌的治愈率，在开始放疗前进行了顺铂动脉内灌注化疗（I-A化疗）。25例中心型大肿瘤（CT扫描前后径超过5cm）患者接受了I-A化疗。将导管选择性插入子宫动脉。顺铂剂量为120mg/m²。化疗后，所有患者均接受放疗。接受I-A化疗的25例患者中有18例可评估。7例患者（38.8%）出现部分肿瘤退缩（测量直径缩小超过50%）。I-A化疗联合放疗的生存率（Kaplan-Meier法）显著高于仅接受传统放疗的23例患者。I-A化疗的毒性与全身给药相似。有3例导管并发症。顺铂动脉内化疗后放疗对晚期子宫颈癌有效。
