Zhang X, Joles J A, Koomans H A, van Tol A, Beynen A C
Department of Nutrition and Food Hygiene, Shanxi Medical College, Taiyuan, People's Republic of China.
J Nutr. 1992 Mar;122(3):520-7. doi: 10.1093/jn/122.3.520.
Female Nagase analbuminemic rats and Sprague-Dawley rats were fed purified diets with or without 1% cholesterol and containing either soybean protein or casein. After consuming the cholesterol-free diets, the analbuminemic rats had significantly higher plasma cholesterol and triglyceride concentrations than the Sprague-Dawley rats. The higher plasma cholesterol levels were essentially in the low density and high density lipoproteins. Based on the fact that the analbuminemic rats excreted more bile acids in feces it is possible that the higher baseline plasma cholesterol concentrations in Nagase analbuminemic rats were partly caused by overproduction of cholesterol. The Nagase analbuminemic rats displayed a greater cholesterolemic response to cholesterol feeding than Sprague-Dawley rats, but only if casein was the protein source in the diet. Casein vs. soybean protein in either cholesterol-free or high cholesterol diets reduced bile acid excretion in Sprague-Dawley but not in Nagase analbuminemic rats. The increased sensitivity to casein plus cholesterol feeding in Nagase analbuminemic rats may be caused by a lack of inhibition of de novo cholesterol synthesis.
给长濑无白蛋白血症雌性大鼠和斯普拉格-道利大鼠喂食含或不含1%胆固醇且含有大豆蛋白或酪蛋白的纯化日粮。在食用无胆固醇日粮后，无白蛋白血症大鼠的血浆胆固醇和甘油三酯浓度显著高于斯普拉格-道利大鼠。较高的血浆胆固醇水平主要存在于低密度和高密度脂蛋白中。基于无白蛋白血症大鼠粪便中排泄更多胆汁酸这一事实，长濑无白蛋白血症大鼠较高的基线血浆胆固醇浓度可能部分是由胆固醇过量产生所致。长濑无白蛋白血症大鼠对喂食胆固醇的胆固醇血症反应比斯普拉格-道利大鼠更大，但前提是日粮中的蛋白质来源为酪蛋白。在无胆固醇或高胆固醇日粮中，酪蛋白与大豆蛋白相比，会减少斯普拉格-道利大鼠的胆汁酸排泄，但对长濑无白蛋白血症大鼠无此影响。长濑无白蛋白血症大鼠对酪蛋白加胆固醇喂食的敏感性增加可能是由于缺乏对从头合成胆固醇的抑制作用。
