Johnston P A, Chahl L A
Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, N.S.W., Australia.
Neurosci Lett. 1992 Jan 20;135(1):23-7. doi: 10.1016/0304-3940(92)90127-s.
The effects of ascorbic acid (AA) were investigated on the morphine withdrawal response of guinea-pigs, a species which shares with man the inability to synthesize AA. Chronic pretreatment of guinea-pigs with AA, 1 g/l, in drinking water for 3 days, or AA 200 mg/kg subcutaneously (s.c.) 3 times daily for 3 days, markedly reduced the locomotor and behavioural withdrawal responses of guinea-pigs given naloxone hydrochloride, 15 mg/kg s.c. 2 h after a single dose of morphine sulphate, 15 mg/kg s.c. AA, 1 g/kg given intraperitoneally (i.p.) 30 min before morphine had no significant effect on morphine withdrawal. However, intracerebroventricular injection of AA, 1 mumol, 30 min before naloxone significantly enhanced morphine withdrawal. It is concluded that chronic but not acute administration of AA inhibits opiate withdrawal.
研究了抗坏血酸（AA）对豚鼠吗啡戒断反应的影响，豚鼠与人一样无法合成AA。给豚鼠连续3天饮用含1 g/L AA的水进行慢性预处理，或每天皮下注射（s.c.）3次200 mg/kg AA，持续3天，可显著降低皮下注射15 mg/kg盐酸纳洛酮的豚鼠在皮下注射15 mg/kg硫酸吗啡单剂量2小时后的运动和行为戒断反应。在吗啡给药前30分钟腹腔注射（i.p.）1 g/kg AA对吗啡戒断无显著影响。然而，在纳洛酮给药前30分钟脑室内注射1 μmol AA可显著增强吗啡戒断反应。结论是，AA的慢性而非急性给药可抑制阿片类药物戒断。
