疑核区域参与动脉血压调节。

The nucleus ambiguus region participates in arterial pressure regulation.

作者信息

Machado B H, Brody M J

机构信息

Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.

出版信息

Neurosci Lett. 1992 Jan 20;135(1):91-4. doi: 10.1016/0304-3940(92)90143-u.

DOI:10.1016/0304-3940(92)90143-u

PMID:1542443

Abstract

Bilateral microinjections of lidocaine into the nucleus ambiguus produced a significant increase of mean arterial pressure. Electrical stimulation of the nucleus ambiguus produced pressor and bradycardic responses, which are abolished by injection of lidocaine into the rostral ventrolateral medulla. These data indicate that the pressor and bradycardic responses produced by electrical stimulation of the nucleus ambiguus depend on the integrity of the rostral ventrolateral medulla. We conclude that the nucleus ambiguus region is involved in the central neural control of arterial pressure through a possible neuronal inhibitory projection to the rostral ventrolateral medulla.

摘要

向疑核双侧微量注射利多卡因可使平均动脉压显著升高。电刺激疑核可产生升压和心动过缓反应，而向延髓头端腹外侧注射利多卡因可消除这些反应。这些数据表明，电刺激疑核所产生的升压和心动过缓反应依赖于延髓头端腹外侧的完整性。我们得出结论，疑核区域可能通过对延髓头端腹外侧的神经元抑制性投射参与动脉血压的中枢神经控制。