Gréger J, Czeizel E, Rácz J
Országos Közegészségügyi Intézet, Budapest.
Orv Hetil. 1992 Feb 16;133(7):407-8, 413-5.
The data of the Hungarian Case-Control Surveillance of Congenital Anomalies, 1980-1987 were evaluated concerning drug intake during pregnancy in 10,698 index patients, 21,564 negative controls and 828 positive controls. Excluding pregnancy supplements, the proportion of no drug users was about 30% and the mean number of drugs used was 2.0 in negative control group. These figures did not differ significantly from data of study and positive control groups. The analysis of most commonly used drugs indicated an extremely high proportion of hormonal support therapy. The teratogenic effect of several human teratogenic drugs was confirmed. However, their use is relatively rare and their attributable risk within the etiology of congenital anomalies is low, at about 0.3-1.0%. At present the teratogenic risk of drugs in humans is exaggerated and it has several unfortunate con-sequences: negligence of necessary drug use, unnecessary anxiety in pregnant women, termination of planned pregnancies without any reasonable cause.
对匈牙利1980 - 1987年先天性异常病例对照监测的数据进行了评估，涉及10698名索引患者、21564名阴性对照和828名阳性对照在孕期的药物摄入情况。排除孕期补充剂后，阴性对照组中未使用药物者的比例约为30%，平均用药数量为2.0。这些数据与研究组和阳性对照组的数据无显著差异。对最常用药物的分析表明，激素支持疗法的比例极高。几种人类致畸药物的致畸作用得到了证实。然而，它们的使用相对较少，在先天性异常病因中的归因风险较低，约为0.3 - 1.0%。目前，人类药物的致畸风险被夸大了，这产生了一些不幸的后果：忽视必要的药物使用、孕妇不必要的焦虑、无合理原因终止计划妊娠。
