Ghosh A, Shatz C J
Department of Neurobiology, Stanford University School of Medicine, CA 94305.
Science. 1992 Mar 13;255(5050):1441-3. doi: 10.1126/science.1542795.
During development of the mammalian visual system, axon terminals of lateral geniculate nucleus (LGN) neurons, initially intermixed within layer 4 of the visual cortex, gradually segregate according to eye preference to form ocular dominance columns. In addition to LGN axons and layer 4 neurons, subplate neurons may also participate in interactions leading to column formation. Deletion of subplate neurons before the formation of ocular dominance columns prevents the segregation of LGN axons within layer 4. Thus, interactions between LGN axons and layer 4 neurons are not sufficient; subplate neurons are also required for formation of ocular dominance columns in the visual cortex.
在哺乳动物视觉系统的发育过程中，外侧膝状核（LGN）神经元的轴突终末最初混合在视觉皮层第4层内，随后根据眼优势逐渐分离，形成眼优势柱。除了LGN轴突和第4层神经元外，皮层下板层神经元也可能参与导致柱形成的相互作用。在眼优势柱形成之前删除皮层下板层神经元会阻止LGN轴突在第4层内的分离。因此，LGN轴突与第4层神经元之间的相互作用是不够的；视觉皮层中眼优势柱的形成也需要皮层下板层神经元。
