瘤型麻风：鼻部表现及米诺环素治疗
Lepromatous leprosy: nasal manifestations and treatment with minocycline.
作者信息
Lalwani A K, Tami T A, Gelber R H
机构信息
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco 94143.
出版信息
Ann Otol Rhinol Laryngol. 1992 Mar;101(3):261-4. doi: 10.1177/000348949210100310.
Nasal involvement in lepromatous leprosy is universal and occurs early in the course of the disease. Nasal symptoms include obstruction, crusting, bleeding, and hyposmia. Traditional therapy with dapsone, rifampin, and clofazimine is limited by its cost and toxicity. Minocycline hydrochloride, a tetracycline antibiotic with limited side effects, is promising as a new treatment for leprosy. A case is presented that highlights the clinical presentation, diagnosis, and treatment of lepromatous leprosy.
瘤型麻风的鼻部受累很普遍，且在疾病进程早期就会出现。鼻部症状包括鼻塞、结痂、出血和嗅觉减退。传统的氨苯砜、利福平及氯法齐明联合疗法存在费用高和毒性大的局限性。盐酸米诺环素是一种副作用有限的四环素类抗生素，有望成为麻风病的一种新疗法。本文报告了1例瘤型麻风病例，突出显示了其临床表现、诊断及治疗情况。
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