Hashimoto T, Takeuchi A
Teikyo University School of Medicine, Tokyo, Japan.
Curr Opin Rheumatol. 1992 Feb;4(1):31-4.
Behçet's disease is a systemic inflammatory disorder capable of inducing thrombophlebitis. Clinicopathologically, it is characterized by neutrophil and platelet hyperfunction. Lesions are formed presumably because neutrophils infiltrating the affected tissue release active oxygen and lysosomal enzymes in large amounts. The mechanism of neutrophil hyperfunction was obscure, but in recent years attention has focused on the effects of cytokines released by mononuclear cells. As more has been learned about the etiopathogenesis of Behçet's disease, novel anti-inflammatory drugs, immunosuppressants, anti-thrombotic agents, and anticoagulants have helped to achieve remarkable progress in treatment. Particularly notable is the effect on severe uveitis of cyclosporine, which is more effective than colchicine and conventional immunosuppressants. With the advent of cyclosporine, the number of patients with Behçet's disease who lose their eyesight has clearly decreased.
白塞病是一种能够引发血栓性静脉炎的全身性炎症性疾病。在临床病理学上，其特征为中性粒细胞和血小板功能亢进。病变的形成可能是因为浸润到受影响组织中的中性粒细胞大量释放活性氧和溶酶体酶。中性粒细胞功能亢进的机制尚不清楚，但近年来，人们的注意力集中在单核细胞释放的细胞因子的作用上。随着对白塞病病因发病机制的了解越来越多，新型抗炎药、免疫抑制剂、抗血栓药物和抗凝剂在治疗方面取得了显著进展。特别值得注意的是环孢素对严重葡萄膜炎的疗效，它比秋水仙碱和传统免疫抑制剂更有效。随着环孢素的出现，白塞病患者失明的人数明显减少。
