Nolting S, Bräutigam M
Department of Dermatology, University of Münster, Germany.
Br J Dermatol. 1992 Feb;126 Suppl 39:56-60. doi: 10.1111/j.1365-2133.1992.tb00012.x.
The antibacterial efficacy of 1% terbinafine cream and 0.1% gentamicin sulphate cream was evaluated in 33 patients with superficial staphylococcal pyoderma in a double-blind contralateral comparison. After 12 days of active treatment, Staphylococcus aureus could be grown from only one out of 33 patients using terbinafine vs no patient using gentamicin. At the end of the study, a marked improvement in clinical symptoms was observed with no significant difference between the two therapies. Despite reviewing the patients three times during the course of the study, no adverse events were reported. The results of this study demonstrate that terbinafine has clinically relevant antibacterial properties which may be useful not only in pyoderma, but also in mixed fungal/bacterial infections, such as athlete's foot.
在一项双盲对侧对照研究中，对33例浅表性葡萄球菌脓皮病患者评估了1%特比萘芬乳膏和0.1%硫酸庆大霉素乳膏的抗菌疗效。经过12天的积极治疗，使用特比萘芬的33例患者中只有1例培养出金黄色葡萄球菌，而使用庆大霉素的患者无一例培养出该菌。在研究结束时，观察到临床症状有显著改善，两种治疗方法之间无显著差异。尽管在研究过程中对患者进行了三次复查，但未报告不良事件。本研究结果表明，特比萘芬具有临床相关的抗菌特性，这不仅可能对脓皮病有用，而且对混合性真菌/细菌感染（如足癣）也可能有用。
