Bell F P, Gerrity R G
Metabolic Diseases Research Upjohn Company, Kalamazoo, Mich. 49001.
Arterioscler Thromb. 1992 Feb;12(2):155-62. doi: 10.1161/01.atv.12.2.155.
Circulating blood monocytes were isolated from normal and hypercholesterolemic swine, and the monocyte lipid compositions and lipid biosynthesis profiles were assessed. The data indicate that monocytes freshly isolated from hyperlipemic swine have increased phospholipid and cholesterol contents and have increased biosynthetic capability for synthesizing phospholipids, triglycerides, and cholesteryl esters, but not cholesterol. The profile of the stimulated lipid synthesis capability is similar to that of the swine aortic intima undergoing atherogenic change. These studies indicate that circulating blood monocytes in hyperlipemic swine, which are known to give rise to intimal foam cells in the early fatty streak lesion, can contribute to altered vessel lipid metabolism without a requirement for in situ modification by wall factors.
从正常猪和高胆固醇血症猪中分离循环血液单核细胞，并评估单核细胞的脂质组成和脂质生物合成谱。数据表明，从高脂血症猪中新鲜分离的单核细胞具有增加的磷脂和胆固醇含量，并且具有增加的合成磷脂、甘油三酯和胆固醇酯（但不包括胆固醇）的生物合成能力。刺激后的脂质合成能力谱与发生动脉粥样硬化变化的猪主动脉内膜相似。这些研究表明，高脂血症猪中的循环血液单核细胞（已知其在早期脂肪条纹病变中产生内膜泡沫细胞）可以导致血管脂质代谢改变，而无需壁因子进行原位修饰。
