Freiman J P, Graham D J, Reed T G, McGoodwin E B
Division of Epidemiology and Surveillance, Food and Drug Administration, Rockville, Maryland 20857.
Perit Dial Int. 1992;12(1):57-60.
The Food and Drug Administration has received 51 reports of cases in the United States in which chemical peritonitis was associated with the intraperitoneal administration of sterile vancomycin hydrochloride, USP intravenous. The clinical presentation of the cases ranged from mild (cloudy dialysate alone) to more severe (severe abdominal pain and fever). The temporal circumstances suggest that intraperitoneal vancomycin may be associated with chemical peritonitis. A positive rechallenge was reported in 9 cases. The underlying mechanism responsible for this adverse reaction has not yet been identified.
美国食品药品监督管理局已收到51例在美国发生的病例报告，这些病例中化学性腹膜炎与腹腔注射USP静脉用无菌盐酸万古霉素有关。这些病例的临床表现从轻度（仅透析液浑浊）到更严重（严重腹痛和发热）不等。从时间情况来看，腹腔内注射万古霉素可能与化学性腹膜炎有关。9例报告了再次用药阳性反应。尚未确定导致这种不良反应的潜在机制。
