Bailie G R, Morton R, Ganguli L, Keaney M, Waldek S
Nephron. 1987;46(3):316-8. doi: 10.1159/000184374.
A clinical and pharmacokinetic study was carried out to determine whether an intraperitoneal (IP) loading dose of vancomycin was as effective as an intravenous (IV) load in the treatment of continuous ambulatory peritoneal dialysis (CAPD)-associated gram-positive peritonitis. Each patient continued a 14-day treatment on IP maintenance doses. All cases of peritonitis (10 in each group) were eradicated. Side effects occurred in 3 patients following IV vancomycin and in none following IP vancomycin. Serum and peritoneal vancomycin concentrations equilibrated fully and rapidly with each route. It is concluded that an IP loading dose of vancomycin, followed by IP maintenance doses, is as effective as and produces fewer side effects than an IV loading dose in the treatment of CAPD peritonitis.
进行了一项临床和药代动力学研究，以确定腹腔内（IP）负荷剂量的万古霉素在治疗持续性非卧床腹膜透析（CAPD）相关革兰氏阳性腹膜炎方面是否与静脉内（IV）负荷剂量一样有效。每位患者继续接受14天的IP维持剂量治疗。所有腹膜炎病例（每组10例）均得到根除。静脉注射万古霉素后有3例患者出现副作用，而腹腔注射万古霉素后无副作用发生。血清和腹膜中的万古霉素浓度通过每种给药途径均能迅速完全平衡。得出的结论是，在治疗CAPD腹膜炎时，腹腔内负荷剂量的万古霉素继以腹腔内维持剂量，与静脉内负荷剂量一样有效，且副作用更少。
