Lobert S, Correia J J
University of Mississippi Medical Center School of Nursing, Jackson 39216.
Cancer Nurs. 1992 Feb;15(1):22-33.
Many agents used in cancer chemotherapy act on a specific phase of the cell cycle and are classified as cell cycle-specific. Some of these cell cycle-specific drugs, the antimitotics, interact with tubulin, the major protein of mitotic spindles, and cause metaphase arrest, thus halting mitosis. Understanding the dynamic processes involved in tubulin polymerization/depolymerization and how chemotherapeutic agents disrupt these processes is fundamental to understanding and anticipating common adverse effects and planning nursing interventions.
许多用于癌症化疗的药物作用于细胞周期的特定阶段，被归类为细胞周期特异性药物。其中一些细胞周期特异性药物，即抗有丝分裂药物，与微管蛋白相互作用，微管蛋白是有丝分裂纺锤体的主要蛋白质，并导致中期停滞，从而使有丝分裂停止。了解微管蛋白聚合/解聚所涉及的动态过程以及化疗药物如何破坏这些过程，对于理解和预测常见不良反应以及规划护理干预措施至关重要。
