Honavar M, Janota I, Polkey C E
Maudsley Hospital, Institute of Psychiatry, Denmark Hill, London.
Dev Med Child Neurol. 1992 Jan;34(1):3-14. doi: 10.1111/j.1469-8749.1992.tb08558.x.
Nineteen patients with Rasmussen's encephalitis were studied, using light-microscopy, immunohistochemistry and in some cases electron-microscopy. Although there was inflammation, no causative agent was identified. 10 patients underwent hemispherectomy and with one exception did well, while local resection for seven produced little or no improvement. For two patients biopsy with subpial transection was beneficial, although a third had a poor response, necessitating subsequent hemispherectomy. Surgical treatment of these patients is justified by a beneficial outcome. Neuropathological study of the resected material is essential for diagnosis and management of this condition.
对19例患有拉斯穆森脑炎的患者进行了研究，采用了光学显微镜、免疫组织化学方法，部分病例还采用了电子显微镜检查。尽管存在炎症，但未发现病原体。10例患者接受了大脑半球切除术，除1例情况不佳外，其余恢复良好；而7例行局部切除术的患者几乎没有改善或毫无改善。对于2例患者，软膜下横切活检是有益的，尽管第3例反应不佳，随后需要进行大脑半球切除术。这些患者的手术治疗因其良好的效果而合理。对切除组织进行神经病理学研究对于该疾病的诊断和治疗至关重要。
