Jones K H, Adler W H
Immunol Commun. 1978;7(6):645-59. doi: 10.3109/08820137809068725.
The length of time mice were able to show a secondary cell-mediated response after a tumor allograft was investigated. C57B1/6 mice were inoculated ip with P-815 mastocytoma cells and, at selected time intervals up to 12 months after immunization, spleen cells were placed in JLC in an attempt to generate secondary CTL activity. It was found, as measured by the 51Cr-release assay, that all mice tested had significant secondary CTL activity 3 months after allograft. The ability to generate a secondary response then decreased with considerable individual variation up to 6 months post-immunization. No significant difference in CTL activity was found between immunized and age-matched control mice 12 months after tumor allograft.
研究了小鼠在肿瘤同种异体移植后能够表现出二次细胞介导反应的时间长度。将C57B1/6小鼠腹腔注射P-815肥大细胞瘤细胞，并在免疫后长达12个月的选定时间间隔，将脾细胞置于JLC中，试图产生二次CTL活性。通过51Cr释放试验测量发现，所有测试小鼠在同种异体移植后3个月都有显著的二次CTL活性。然后，产生二次反应的能力在免疫后6个月内下降，个体差异相当大。肿瘤同种异体移植12个月后，免疫小鼠和年龄匹配的对照小鼠之间的CTL活性没有显著差异。
