孕11至20周整倍体和非整倍体胎儿的鼻骨长度：一项前瞻性研究。
Fetal nasal bone length in euploid and aneuploid fetuses between 11 and 20 weeks' gestation: a prospective study.
作者信息
Cusick William, Provenzano Jacquelyn, Sullivan Christopher A, Gallousis Francene M, Rodis John F
机构信息
Division of Maternal-Fetal Medicine, The Stamford Hospital, Shelburne at West Broad Street, Stamford, CT 06904, USA.
出版信息
J Ultrasound Med. 2004 Oct;23(10):1327-33. doi: 10.7863/jum.2004.23.10.1327.
OBJECTIVE
To develop normative data for nasal bone length between 11 and 20 weeks' gestation and to assess the utility of nasal bone hypoplasia in the detection of fetal aneuploidy in the second trimester.
METHODS
Well-dated, nonanomalous fetuses were examined between 11 and 20.9 weeks' gestation. The nasal bone was assessed and measured, and normative data from 11 to 20 weeks' gestation were determined. The nasal bone lengths in fetuses with confirmed aneuploidy were compared with the normative data.
RESULTS
The fetal nasal bone length increased linearly with advancing gestational age. Nomograms including the 10th, 50th, and 90th percentiles were created. Nasal bone hypoplasia was seen in 6 of 6 cases of fetal trisomy in the second trimester.
CONCLUSIONS
Nasal bone hypoplasia in the early second trimester identifies a cohort of fetuses at high risk for aneuploidy.
目的
制定孕11至20周鼻骨长度的正常参考数据，并评估孕中期鼻骨发育不全在检测胎儿非整倍体中的作用。
方法
对孕11至20.9周的孕周明确、无异常的胎儿进行检查。评估并测量鼻骨，确定孕11至20周的正常参考数据。将确诊为非整倍体胎儿的鼻骨长度与正常参考数据进行比较。
结果
胎儿鼻骨长度随孕周增加呈线性增长。绘制了包含第10、50和90百分位数的列线图。孕中期6例胎儿三体综合征中有6例出现鼻骨发育不全。
结论
孕中期早期鼻骨发育不全可识别出一组非整倍体高风险胎儿。
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